The DNA Damage-Sensing NER Repair Factor XPC-RAD23B Does Not Recognize Bulky DNA Lesions with a Missing Nucleotide Opposite the Lesion.
K. M. Feher, A. Kolbanovskiy, A. Durandin, Y. Shim, J. H. Min, Y. C. Lee, V. Shafirovich, H. Mu, S. Broyde, N. E. Geacintov
This study shows that XPC-RAD23B does not bind to DNA lesions with a missing nucleotide opposite the lesion, due to structural stabilization preventing XPC binding.
bioRxiv · Sep 14, 2020Biochemistry