Author

A. L. Lee

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:protein folding & dynamics· 2 Assay:protein structure· 2

Frequent Co-Authors

A. Jain· 1 shared H. Y. Hsieh· 1 shared J. Aubè· 1 shared K. C. Chen· 1 shared K. Li· 1 shared M. M. Currie· 1 shared N. V. Dokholyan· 1 shared P. J. Sapienza· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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1 shared paperBiophysics

A. Jain

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3 papers

Recent·Most cited

Allosteric inactivation of an engineered optogenetic GTPase

A. Jain, N. V. Dokholyan, A. L. Lee

This paper uses NMR spectroscopy to study how light-induced allosteric changes in the Cdc42Lov fusion protein inhibit GTPase signaling, revealing structural and dynamic mechanisms of optogenetic control.

bioRxiv · May 16, 2022 · PreprintBiophysics

CuAAC stabilization of an NMR mixed labeled dimer

P. J. Sapienza, M. M. Currie, K. Li, J. Aubè, A. L. Lee

The paper describes methods to produce pure, active mixed isotopically labeled dimer of chorismate mutase using CuAAC for structural studies of allostery.

bioRxiv · May 24, 2021 · PreprintBiophysics

Hyaluronic Acid on the Urokinase Sustained Release with a Hydrogel System Composed of Poloxamer 407: Enhanced Stability of Intracellular Interaction by Adding HA.

H. Y. Hsieh, W. Y. Lin, A. L. Lee, Y. C. Li, Y. J. Chen, K. C. Chen, T.-H. Young

This paper develops a thermo-responsive hydrogel combining poloxamer 407 and hyaluronic acid to improve urokinase delivery for pleural empyema treatment, showing enhanced stability and reduced toxicity.

bioRxiv · Dec 31, 2019Pharmacology & Toxicology