Hyaluronic Acid on the Urokinase Sustained Release with a Hydrogel System Composed of Poloxamer 407: Enhanced Stability of Intracellular Interaction by Adding HA.
H. Y. Hsieh, W. Y. Lin, A. L. Lee, Y. C. Li, Y. J. Chen, K. C. Chen, T.-H. Young
This paper develops a thermo-responsive hydrogel combining poloxamer 407 and hyaluronic acid to improve urokinase delivery for pleural empyema treatment, showing enhanced stability and reduced toxicity.
bioRxiv · Dec 31, 2019Pharmacology & Toxicology