Chk1 Phosphorylates Cdh1 to Promote SCFβTRCP-Dependent Degradation of Cdh1 During S-Phase
D. Pal, A. E. Torres, A. L. Messina, A. Dickson, K. De, B. Willard, M. Venere, M. K. Summers
This study shows Chk1 phosphorylates Cdh1 to promote its SCFβTRCP-dependent degradation during S-phase, facilitating efficient S-phase entry and cellular proliferation.
bioRxiv · Feb 5, 2019Cell Biology