The histone methyltransferase SETD2 regulates HIV expression and latency through a post-transcriptional mechanism.
C. R. Bussey-Sutton, A. Ward, A.-M. W. Turner, J. J. Peterson, A. Emery, A. Longoria, D. M. Margolis, B. Strahl, E. P. Browne
This study shows that SETD2 inhibition reduces HIV gene expression and latency by altering viral RNA splicing, not transcription.
bioRxiv · Dec 15, 2023 · PreprintMicrobiology