Non-conservation of folding rates in the thioredoxin family reveals degradation of ancestral unassisted-folding
G. Gamiz-Arco, V. A. Risso, A. M. Candel, A. Ingles-Prieto, M. L. Romero-Romero, E. A. Gaucher, J. A. Gavira, B. Ibarra-Molero, J. M. Sanchez-Ruiz
The paper analyzes folding rates of thioredoxins across species and finds that modern variants fold slower than ancestral ones, suggesting degradation of unassisted folding.
bioRxiv · Oct 3, 2019Biophysics