J. M. Sanchez-Ruiz

This study engineers an ancestral β-lactamase to efficiently catalyze Kemp elimination, achieving catalytic parameters comparable to modern enzymes.

This study engineers a symbiont thioredoxin for efficient heterologous expression by resurrecting ancestral proteins and optimizing folding rates.

This study shows that virus adaptation can occur through phenotypic mutations rather than genetic mutations in the viral DNA polymerase.

The paper analyzes folding rates of thioredoxins across species and finds that modern variants fold slower than ancestral ones, suggesting degradation of unassisted folding.