Inhibitor-based modulation of huntingtin aggregation mechanisms mitigates fibril-induced cellular stress.
G. Jain, M. Trombetta-Lima, I. Matlahov, H. Taborda Ribas, T. Chen, R. Parlato, G. Portale, A. M. Dolga, P. C. A. van der Wel
This study shows that curcumin modulates huntingtin aggregation, reducing cellular stress by altering fibril structure and metabolic properties.
bioRxiv · Apr 24, 2023Biophysics