Thermo-amplifier circuit in probiotic E. coli for stringently temperature-controlled release of a novel antibiotic
S. Dey, C. E. Seyfert, C. Fink-Straube, A. M. Kany, R. Mueller, S. Sankaran
The paper develops a thermo-amplifier circuit in probiotic E. coli to control the release of darobactin, a peptide antibiotic, at 40°C while maintaining low leakiness at 37°C.
bioRxiv · Feb 13, 2024 · PreprintBioengineering