BiophysicsbioRxiv
RNA-mediated Allosteric Activation in CRISPR-Cas13a
S. Sinha, A. M. Molina Vargas, P. R. Arantes…·G. Palermo
This study elucidates the allosteric activation mechanism of CRISPR-Cas13a using molecular dynamics simulations and experiments, revealing key residues critical for RNA cleavage selectivity.
DOI 10.1093/nar/gkad1127