Author

P. R. Arantes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biophysics· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:protein folding & dynamics· 3 Approach:biophysical modeling· 2 Approach:deep learning· 1 Approach:experimental assay· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

G. Palermo· 4 shared A. Saha· 2 shared M. Jinek· 2 shared A. C. Patel· 1 shared A. Clery· 1 shared A. M. Molina Vargas· 1 shared C. Chanez· 1 shared C.-H. Lin· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersBiophysics

G. Palermo

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

RNA-mediated Allosteric Activation in CRISPR-Cas13a

S. Sinha, A. M. Molina Vargas, P. R. Arantes, A. C. Patel, M. R. O'Connell, G. Palermo

This study elucidates the allosteric activation mechanism of CRISPR-Cas13a using molecular dynamics simulations and experiments, revealing key residues critical for RNA cleavage selectivity.

bioRxiv · Jul 27, 2023Biophysics

An Alpha-helical Lid Guides the Target DNA toward Catalysis in CRISPR-Cas12a

A. Saha, M. Ahsan, P. R. Arantes, M. Schmitz, C. Chanez, M. Jinek, G. Palermo

This study reveals how the alpha-helical lid in CRISPR-Cas12a guides the DNA target strand toward the RuvC catalytic core through molecular dynamics simulations and experiments.

bioRxiv · Sep 5, 2022Biophysics

Structural basis for Cas9 off-target activity

M. Pacesa, C.-H. Lin, A. Clery, A. Saha, P. R. Arantes, K. Bargsten, M. J. Irby, F. H. Allain, G. Palermo, P. Cameron, P. D. Donohoue, M. Jinek

This study identifies structural mechanisms enabling Cas9 off-target activity through non-canonical base pairing and conformational changes.

bioRxiv · Nov 18, 2021Biochemistry

Enhanced Specificity Mutations Perturb Allosteric Signaling in CRISPR-Cas9

G. Palermo, L. Nierzwicki, K. W. East, U. N. Morzan, P. R. Arantes, G. P. Lisi, V. S. Batista

The paper investigates how specificity-enhancing mutations in CRISPR-Cas9 affect allosteric signaling, showing that mutations like K855A disrupt the HNH domain structure and signaling transfer more than others.

bioRxiv · Sep 14, 2021Biophysics