Surface proteins of SARS-CoV-2 drive airway epithelial cells to induce interferon-dependent inflammation
G. Anand, A. M. Perry, C. L. Cummings, E. S. Raymond, R. A. Clemens, A. L. Steed
This study shows SARS-CoV-2 surface proteins Spike and Envelope activate the IFN pathway in immune and epithelial cells, induce inflammation, and contribute to lung pathology in mice.
bioRxiv · Dec 14, 2020Immunology