Guiding dose selection of monoclonal antibodies using a new parameter (AFTIR) for characterizing ligand binding systems
S. Ahmed, M. Ellis, H. Li, L. Pallucchini, A. M. Stein
The paper introduces a new metric, AFTIR, to guide monoclonal antibody dose selection by simplifying complex target-mediated drug disposition models into four key parameters.
bioRxiv · Feb 6, 2019Pharmacology & Toxicology