S. Ahmed

Engineered Cardiac Microtissue Biomanufacturing Using Human Induced Pluripotent Stem Cell-Derived Epicardial Cells

This study characterizes human induced pluripotent stem cell-derived epicardial cells for cardiac tissue engineering, identifying optimal differentiation stages and their functional roles in 3D microtissue formation.

Airway injury induces alveolar epithelial responses mediated by macrophages

This study shows that airway injury triggers alveolar type 2 cell proliferation mediated by macrophages, revealing a myeloid-driven response in the lung.

Alternative substitutions of N332 in HIV-1AD8 gp120 differentially affect envelope glycoprotein function and viral sensitivity to broadly neutralizing antibodies targeting the V3-glycan

This study examines how different amino acids at position 332 of HIV-1AD8 gp120 affect viral sensitivity to antibodies, cold exposure, and infectivity.

CD8 T-cell dysfunction is linked with CAR T-cell failure and can be mitigated by a non-alpha IL-2 agonist, pegenzileukin

The paper identifies dysfunctional CD8 CAR T-cells in rrLBCL tumors and shows that pegenzileukin mitigates this dysfunction, improving CAR T-cell responses.

Glyceroglycolipids are essential for Burkholderia cenocepacia intracellular survival by preventing phagolysosome acidification

Wat1/mLst8, a TOR complex protein regulates mitochondrial integrity and calcium ion homeostasis in fission yeast S. pombe

This study shows Wat1/mLst8 regulates mitochondrial integrity, calcium homeostasis, and respiratory function in fission yeast through interactions with TORC1 and mitochondrial proteins.

Discovery of highly potent small molecule pan-coronavirus fusion inhibitors

This paper discovers and characterizes NBCoV63, a potent small molecule inhibitor effective against multiple SARS-CoV-2 variants and other coronaviruses.

Susceptible bacteria survive antibiotic treatment in the mammalian gastrointestinal tract without evolving resistance

The paper shows that gut bacteria can survive antibiotic treatment without developing resistance by acquiring mutations that enhance their ability to persist and invade intestinal cells.

Individual Decision-Making Underlying the Tragedy of the Commons

The paper studies individual decision-making in group resource use, finding that resource overuse is influenced by individual attitudes and remaining resource levels.

Compartmentation of putrescine synthesis in plants

This study identifies the subcellular localization of enzymes involved in putrescine synthesis in plants, revealing compartmentalization in chloroplasts, ER, and mitochondria.

CryoEM structure of QacA, an antibacterial efflux transporter from Staphylococcus aureus

The paper reports the cryoEM structure of QacA, an antibacterial efflux transporter, and provides insights into its conformational dynamics and function.

Metabolic Implications of Birth via Cesarean Section in Prairie Vole (Microtus ochrogaster)

This study investigates the metabolic differences between prairie voles born via cesarean section (CS) and vaginal delivery (VD), finding that CS voles gain more weight and have higher brown adipose tissue despite lower food intake.

Ter-Seq: A high-throughput method to stabilize transient ternary complexes and measure associated kinetics

The paper introduces Ter-Seq, a method to stabilize ternary complexes and measure kinetics using CcdA-CcdB-GyrA14 as a model, identifying mutations that affect complex formation and rejuvenation rates.

Immunopharmacological evaluation of adjuvant efficacy of Monophosphoryl lipid-A and CpG ODN with SARS-CoV-2 RBD antigen

The paper evaluates the immunopharmacological efficacy of MPL-A and CpG ODN adjuvants with SARS-CoV-2 RBD antigen, showing they elicit potent antibody responses and enhance T and B cell populations.

Highly Thermotolerant SARS-CoV-2 Vaccine Elicits Neutralising Antibodies Against Delta and Omicron in Mice

This study evaluates a highly thermotolerant SARS-CoV-2 vaccine in mice, showing it elicits neutralizing antibodies against Delta and Omicron variants.

Chemical exploration of a highly selective scaffold with activity against intracellular Mycobacterium tuberculosis

The paper identifies thiourea derivatives with high potency against intracellular Mycobacterium tuberculosis and good selectivity over eukaryotic cells.

Global analysis of biosynthetic gene clusters reveals conserved and unique natural products in entomopathogenic nematode-symbiotic bacteria

The paper analyzes biosynthetic gene clusters in entomopathogenic nematode-symbiotic bacteria to identify conserved and unique natural products and their functional roles.

Using polyacrylamide hydrogels to model physiological aortic stiffness reveals that microtubules are critical regulators of isolated smooth muscle cell morphology and contractility.

This study uses polyacrylamide hydrogels to model aortic stiffness and shows microtubules regulate VSMC morphology and contractility by balancing actomyosin forces.

Mechanistic insights into global suppressors of protein folding defects

The paper identifies global suppressor mutations that rescue protein folding defects and shows they stabilize proteins through refolding rate acceleration, with some providing structural insights.

Identification of novel chemical scaffolds that inhibit the growth of Mycobacterium tuberculosis in macrophages

This study identifies five chemical classes that inhibit intracellular Mycobacterium tuberculosis growth in macrophages, with some also active against extracellular bacteria.

Discovery of highly potent pancoronavirus fusion inhibitors that also effectively inhibit COVID-19 variants from the UK (Alpha), South Africa (Beta), and India (Delta)

The paper identifies potent small molecules that inhibit multiple coronaviruses, including SARS-CoV-2 variants, with high selectivity and in vivo efficacy.

Genome-wide in vivo screen of circulating tumor cells identifies SLIT2 as a regulator of metastasis

This study identifies SLIT2 as a regulator of metastasis through a genome-wide CRISPR screen of circulating tumor cells in a mouse model.

Stabilizing proteins through saturation suppressor mutagenesis.

This paper introduces a method to identify stabilizing protein mutations by screening libraries with destabilizing mutations, demonstrating its effectiveness in enhancing protein stability.

Prediction of residue-specific contributions to binding and thermal stability using yeast surface display

The paper uses yeast surface display to predict residue-specific contributions to binding and thermal stability, showing high accuracy in identifying buried and active-site residues.

Immune microenvironment subtypes and association with tumor cell mutations and antigen expression in follicular lymphoma.

The paper identifies immune microenvironment subtypes in follicular lymphoma linked to tumor mutations and antigen expression, informing potential immunotherapeutic strategies.

Elicitation of potent serum neutralizing antibody responses in rabbits by immunization with an HIV-1 clade C trimeric Env derived from an Indian elite neutralizer

This study shows that immunization with a thermostable HIV-1 clade C Env trimer induces potent autologous neutralizing antibodies in rabbits, with distinct epitope specificity compared to natural infection.

Endosomal cargo recycling mediated by Gpa1 and Phosphatidylinositol-3-Kinase is inhibited by glucose starvation

The paper shows glucose starvation inhibits endosomal cargo recycling by altering PI3K activity through Gpa1 and Gpa2 interactions.

Increased levels of the mitochondrial import factor Mia40 prevent the aggregation of polyQ proteins in the cytosol

The paper shows that overexpressing Mia40 reduces toxic polyQ protein aggregates in yeast and human cells by competing for chaperone and proteasome resources.

Bacteriophage SP01 Gene Product 56 (gp56) Inhibits Bacillus subtilis Cell Division by Interacting with DivIC/FtsL to Prevent Pbp2B/FtsW Recruitment

This paper identifies gp56, a bacteriophage protein, as an inhibitor of Bacillus subtilis cell division by blocking recruitment of late division proteins through interaction with DivIC/FtsL.

Isolation and characterization of L-glutaminase producing bacteria

This study isolates and characterizes L-glutaminase-producing bacteria from Pakistani soil and optimizes conditions for enzyme production.