Human Oocytes Harbouring Damaged DNA Can Complete Meiosis-I
Gaudeline Rémillard‐Labrosse, Nicola L. Dean, Adélaïde Allais, Aleksandar I. Mihajlović, Shao Guang Jin, Weon‐Young Son, Jin-Tae Chung, Melissa Pansera, Sara Henderson, A. Mahfoudh, Naama Steiner, Kristy Agapitou, Petros Marangos, William M Buckett, Jacob Ruiter‐Ligeti, Greg FitzHarris
This study shows that human oocytes with DNA damage can complete meiosis-I and extrude the first polar body, unlike mouse oocytes which arrest due to SAC signalling.
bioRxiv · Sep 5, 2019 · PreprintDevelopmental Biology