Antimalarial drugs lose their activity with a slight drop in pH
T. Kitagawa, A. Mastumoto, I. Terashima, Y. Uesono
The paper shows that antimalarial drugs lose activity with a slight pH drop due to reduced cationic amphiphilic drug (CAD) structure, affecting their efficacy against malaria and COVID-19 in acidotic conditions.
bioRxiv · Aug 4, 2020Pharmacology & Toxicology