Suppression of membranous LRP5 recycling, WNT/β-catenin signaling, and colorectal tumorigenesis by 15-LOX-1 peroxidation of PI3P_linoleic acid
F. Liu, X. Zuo, Y. Liu, Y. Deguchi, M. J. Moussalli, W. Chen, P. Yang, B. Wei, P. L. Lorenzi, S. Gao, J. C. Jaoude, A. Mehdizadeh, L. A. Valentin, D. Wei, I. Shureiqi
This study shows that 15-LOX-1 metabolism of LA in PI3P reduces LRP5 membrane levels, inhibits Wnt/β-catenin signaling, and suppresses colorectal tumorigenesis in mice.
bioRxiv · Aug 29, 2019Cancer Biology