A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptor
Y. Huang, J. Ognjenovic, D. Karandur, K. Miller, A. Merk, S. Subramaniam, J. Kuriyan
This study identifies how EGFR differentiates signaling outputs from EGF and TGF- through conformational changes in its extracellular domain.
bioRxiv · Dec 8, 2020Biochemistry