Y. Huang

Integrated Transcriptomic and Translatomic Profiling Reveals Noncanonical RNA Junctions and Hidden Coding Potential in Porcine Epidemic Diarrhea Virus

This study identifies noncanonical RNA junctions and hidden coding potential in PEDV using integrated transcriptomic and translatomic approaches.

Generative Neural Spike Prediction from Upstream Neural Activity via Behavioral Reinforcement

This paper develops a reinforcement learning framework to predict downstream neural spike trains from upstream activity using behavioral rewards, achieving better behavioral performance than existing methods.

Taking identity-by-descent analysis into the wild: Estimating realized relatedness in free-ranging macaques

The paper estimates realized relatedness in free-ranging macaques using IBD analysis from low coverage whole genome data, revealing genetic variation within kin classes and cryptic relatives.

Mass mortality associated with Carpione Rhabdovirus in golden pompano (Trachinotus ovatus) in China: First report

This study reports the first natural infection of Carpione Rhabdovirus in golden pompano fish in China, associated with high mortality and characterized by viral morphology and genetic analysis.

Hybrid immunity to SARS-CoV-2 arises from serological recall of IgG antibodies distinctly imprinted by infection or vaccination

This study compares IgG antibody responses from SARS-CoV-2 infection, vaccination, and hybrid immunity, finding that hybrid immunity retains the imprint of the initial exposure and enhances antibody breadth and affinity.

ILC2s navigate tissue redistribution during infection using stage-specific S1P receptors

This study shows that ILC2s use different S1P receptors at distinct stages to migrate during infection, highlighting a shared vascular network for lymphocyte movement.

Estimating effective population size trajectories from time-series Identity-by-Descent (IBD) segments

This paper introduces TTNE, a method for inferring recent effective population size trajectories from time-series IBD data, showing improved resolution over methods using contemporaneous samples.

Riluzole reverses blood-testis barrier loss to rescue chemotherapy induced male infertility by binding to TRPC

This study shows riluzole restores blood-testis barrier function and rescues chemotherapy-induced male infertility in mice by targeting TRPC5.

Splenic red pulp macrophages eliminate the liver-resistant Streptococcus pneumoniae during bloodstream infection

The paper identifies that splenic red pulp macrophages, aided by natural antibodies and complement, clear liver-resistant Streptococcus pneumoniae from the bloodstream in mice.

Nanocluster-antibody-drug conjugates (NADC) as an intravesical precision theranostic agent for interstitial cystitis

This paper develops a nanocluster-antibody-drug conjugate (NADC) for interstitial cystitis, showing it targets NGF-overexpressing bladder lesions and reduces inflammation in rat models.

Divergent lineage trajectories and genetic landscapes in human gastric intestinal metaplasia organoids associated with early neoplastic progression

Mechano-regulation of GLP-1 production by Piezo1 in intestinal L cells

This study shows that Piezo1 in intestinal L cells mechanically regulates GLP-1 production, affecting glucose tolerance and diabetes.

Functional characterization of Lipid storage droplets 1 (LSD1) in growth and lipolysis of Hermetia illucens

This study investigates the role of LSD1 in lipid metabolism of Hermetia illucens, finding it promotes larval growth without affecting fat content or development.

Chalkophomycin Biosynthesis Revealing Unique Enzyme Architecture for a Hybrid Nonribosomal Peptide Synthetase and Polyketide Synthase

The paper identifies and characterizes the chm biosynthetic gene cluster responsible for chalkophomycin production in Streptomyces sp. CB00271 and proposes a biosynthesis model based on sequence analysis and structural modeling.

Non-mechanical disruption of Bacillus subtilis spores allows sensitive and deep characterization of the minimal proteome for resuming a cellular lifestyle.

This paper introduces a new sample preparation method, SPEED, which improves proteomic analysis of Bacillus subtilis spores by identifying more proteins and enabling differentiation between spore and vegetative cell proteins.

The segmented flavivirus Alongshan virus reduces mitochondrial mass via degrading STAT2 to suppress innate immune response

Prevalent fast evolution of genes involved in heterochromatin functions

The paper investigates the evolutionary dynamics of genes involved in heterochromatin functions in Drosophila, finding they evolve faster than Polycomb-based repressive chromatin genes.

Single-cell transcriptome landscape of zebrafish liver reveals hepatocytes and immune cell interactions in understanding nonalcoholic fatty liver disease

The paper uses single-cell RNA sequencing to map zebrafish liver cell types and interactions, identifying macrophage subtypes and their role in nonalcoholic fatty liver disease.

Genomic Mapping Reveals Cisplatin Disruption of Protein Phosphorylation Signalling Genome-Wide

This study identifies 16216 cisplatin-damaged genes in human lung cancer cells and shows cisplatin disrupts protein phosphorylation signalling by targeting 85% of protein kinase and 81% of phosphatase genes.

Targeted NAD+ Delivery for Intimal Hyperplasia and Re-endothelialization: A Novel Anti-restenotic Therapy Approach

This study demonstrates that targeted NAD+ delivery via nanocarriers reduces intimal hyperplasia and promotes endothelial regeneration in a rat model of restenosis.

Unveiling chemotherapy-induced immune landscape remodeling and metabolic reprogramming in lung adenocarcinoma by scRNA-sequencing

This study uses scRNA-seq to analyze how chemotherapy remodels the immune landscape and metabolic state in lung adenocarcinoma, identifying changes in macrophage subtypes and immune responses.

Hist2Cell: Deciphering Fine-grained Cellular Architectures from Histology Images

Hist2Cell predicts fine-grained transcriptional cell types from histology images with high accuracy, enabling cellular mapping and cancer prognosis.

Polygenic architecture of adaptation to a high-altitude environment for Drosophila melanogaster wing shape and size.

This study identifies a polygenic architecture for wing shape and size adaptation in Drosophila melanogaster to high-altitude environments, with one large-effect QTL and many small-effect alleles contributing to divergence.

The full length BEND2 protein is dispensable for spermatogenesis but required for setting the ovarian reserve in mice

This study shows that full-length BEND2 is not needed for male fertility but is essential for establishing the ovarian reserve in mice.

Transcriptional and phenotypic heterogeneity underpinning venetoclax resistance in AML

This study identifies four transcriptionally distinct venetoclax-resistant clusters in AML, revealing phenotypic, genetic, and drug response differences and their implications for treatment resistance.

Self-inspired learning to denoise for live-cell super-resolution microscopy

This paper introduces SN2N, a self-supervised denoising method for live-cell super-resolution microscopy that achieves competitive performance without requiring large clean datasets.

A dual-gene reporter-amplifier architecture for enhancing the sensitivity of molecular MRI by water exchange

This paper develops a dual-gene reporter-amplifier system to enhance MRI sensitivity by using Aqp1 to facilitate water exchange, enabling detection of low-abundance Oatp1b3-expressing cells.

Monocytic fibrocyte-like cell enrichment and myofibroblastic adaptation causes nucleus pulposus fibrosis and associates with disc degeneration severity

The paper identifies fibrocyte-like cells as key drivers of nucleus pulposus fibrosis in disc degeneration, showing their role in myofibroblast formation and disease severity.

Metabolomics unveiled the impact of alterations in nucleotide glucose metabolism on palmitic acid-induced TLR4 activation in THP-1 macrophages

This study uses metabolomics to show that palmitic acid alters N-glycosylation-related metabolites in THP-1 macrophages, linking them to TLR4 activation and inflammation.

Persistence of an infectious form of SARS-CoV-2 post protease inhibitor treatment of permissive cells in vitro

The paper shows that an infectious intermediate form of SARS-CoV-2 persists in vitro after protease inhibitor treatment, potentially explaining viral rebound in patients.