Uncovering nick DNA binding by LIG1 at the single-molecule level
S. Chatterjee, L. Chaubet, A. v. d. Berg, A. Mukhortava, M. Caglayan
This study investigates how LIG1 binds to nick DNA at the single-molecule level, revealing specific and non-specific binding dynamics and the role of the N-terminal region in nick search.
bioRxiv · Mar 28, 2024Biochemistry