Extracellular CIRP as a Novel Endogenous TREM-1 Ligand to Fuel Inflammation
N.-L. Denning, M. Aziz, A. Murao, S. D. Gurien, M. Ochani, J. Prince, P. Wang
This study identifies eCIRP as a novel TREM-1 ligand that drives inflammation in sepsis and develops a peptide M3 to block this interaction and improve outcomes.
bioRxiv · Jun 18, 2019Immunology