Revealing a hidden conducting state by manipulating the intracellular domains in KV10.1 exposes the coupling between two gating mechanisms.
R. Abdelaziz, A. P. Tomczak, A. Neef, L. A. Pardo
The paper investigates KCNH1(KV10.1) channel gating by modifying intracellular domains, revealing a hidden open state and elucidating intermediate gating events.
bioRxiv · Jul 24, 2023Biophysics