Author

A. Niemela

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 2 Approach:statistical model· 2 Approach:deep learning· 1 Approach:mechanistic / dynamical model· 1 Assay:protein structure· 1

Frequent Co-Authors

A. S. Koivuniemi· 2 shared E.-P. Kumpula· 1 shared J. T. Huiskonen· 1 shared L. Giorgi· 1 shared O. Natri· 1 shared P. Parkkila· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 15 mutual co-author links

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2 shared papersBiophysics

A. S. Koivuniemi

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2 papers

Recent·Most cited

Mechanistic insights into the activation of lecithin-cholesterol acyltransferase in therapeutic nanodiscs composed of apolipoprotein A-I mimetic peptides and phospholipids

L. Giorgi, A. Niemela, E.-P. Kumpula, O. Natri, P. Parkkila, J. T. Huiskonen, A. S. Koivuniemi

This study investigates how apoA-I mimetic peptides modulate LCAT activity in nanodiscs through molecular dynamics simulations and experiments, revealing structural and functional insights.

bioRxiv · Jun 9, 2022Biophysics

Positive allosteric modulators of lecithin:cholesterol acyltransferase adjust the orientation of the membrane-binding domain and alter its spatial free energy profile

A. Niemela, A. S. Koivuniemi

This study uses computational methods to investigate how positive allosteric modulators of LCAT affect the orientation and spatial free energy of the membrane-binding domain.

bioRxiv · Oct 20, 2020Biophysics