Author

P. Parkkila

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Research Focus:chromatin & epigenetic regulation· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

A. Koivuniemi· 1 shared A. Niemela· 1 shared A. S. Koivuniemi· 1 shared E.-P. Kumpula· 1 shared J. T. Huiskonen· 1 shared L. Giorgi· 1 shared M. G. Casteleijn· 1 shared O. Natri· 1 shared

Activity by Year

2017-2022 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 18 mutual co-author links

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1 shared paperBiophysics

A. Koivuniemi

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2 papers

Recent·Most cited

Mechanistic insights into the activation of lecithin-cholesterol acyltransferase in therapeutic nanodiscs composed of apolipoprotein A-I mimetic peptides and phospholipids

L. Giorgi, A. Niemela, E.-P. Kumpula, O. Natri, P. Parkkila, J. T. Huiskonen, A. S. Koivuniemi

This study investigates how apoA-I mimetic peptides modulate LCAT activity in nanodiscs through molecular dynamics simulations and experiments, revealing structural and functional insights.

bioRxiv · Jun 9, 2022Biophysics

Interaction of lecithin-cholesterol acyltransferase with lipid surfaces and apolipoprotein A-I derived peptides: implications for the cofactor mechanism of apolipoprotein A-I

M. G. Casteleijn, P. Parkkila, T. Viitala, A. Koivuniemi

This study investigates how LCAT interacts with lipid surfaces and apoA-I peptides to catalyze cholesterol esterification, revealing mechanistic insights into its cofactor mechanism and potential for CHD prevention.

bioRxiv · Dec 15, 2017Biophysics