Enhanced intrathecal drug dispersion achieved by high volume injection and natural micromixing
A. O. Ayansiji, D. S. Gehrke, B. Baralle, A. Nozain, S. R. Meenesh, A. A. Linninger
This study demonstrates that high-volume intrathecal injections enhance drug dispersion throughout the spinal subarachnoid space by leveraging natural CSF oscillations and micro-mixing.
Frontiers in Physiology · Sep 25, 2023Peer-reviewedBioengineering