Novel, provable algorithms for efficient ensemble-based computational protein design and their application to the redesign of the c-Raf-RBD:KRas protein-protein interface
A. U. Lowegard, M. Frenkel, J. Jou, A. Ojewole, G. Holt, B. Donald
This paper introduces two provable algorithms for efficient computational protein design and applies them to redesign the c-Raf-RBD:KRas interface, achieving high accuracy in predicting and validating mutations.
bioRxiv · Oct 2, 2019Biochemistry