Evidence for Free Radical Drug Ligands in class A G-protein Coupled Receptors
L. Turin, E. M. C. Skoulakis, A. P. Horsfield, A. Gehrckens
The paper identifies three cationic ligands in GPCRs that exist as neutral radicals rather than closed shell cations, suggesting a new mechanism for GPCR function.
bioRxiv · Aug 30, 2021 · PreprintPharmacology & Toxicology