Evidence for Free Radical Drug Ligands in class A G-protein Coupled Receptors
Abstract
We analyse the conformation of 22 cationic ligands bound to G-protein coupled receptors of known structure and find three ligands that are present inside receptors not in their closed shell cation form, but as neutral radicals, i.e. after addition of an electron to the ligand. The implications of this finding for GPCR function are discussed and a possible experimental test is proposed.
02 /Specification & Classification
Click any tag to browse matching papers- Approach
Reproducibility ledger
Nobody has reported trying to reproduce this paper yet. Did you replicate an experiment or run the code? Your report saves the next lab a week.
Sign in to file a reproducibility report.
Related papers
- Intracellular Passage Of Na+ In An Active State G Protein Coupled Receptor
o. N. Vickery, C. A. Carvalheda, … U. Zachariae·bioRxiv·Jul 21, 2017
- Anionic Phospholipids Control Mechanisms of GPCR-G Protein Recognition
N. Thakur, A. Ray, … M. Eddy·Nature CommunicationsPeer-reviewed·Feb 13, 2023
- Unique Features of Different Classes of G-Protein-Coupled Receptors Revealed from Sequence Coevolutionary and Structural Analysis
Hung Nguyen Do, Allan Haldane, … Yinglong Miao·Proteins Structure Function and BioinformaticsPeer-reviewed·Oct 4, 2021
- Structure and function of an intermediate GPCR-G protein complex
Maxine Bi, Xudong Wang, … Libin Ye·Nature CommunicationsPeer-reviewed·Jan 28, 2025
- Cryo-EM structure of the rhodopsin-Gαi-βγ complex reveals binding of the rhodopsin C-terminal tail to the Gβ subunit
C.-J. Tsai, J. Marino, … G. F. Schertler·bioRxiv·Feb 12, 2019
- A non-canonical mechanism of GPCR activation
Alexander S. Powers, Aasma A. Khan, … Ron O. Dror·Nature CommunicationsPeer-reviewed·Nov 16, 2024