ZBTB18 inhibits SREBP-dependent fatty acid synthesis by counteracting CTBPs and KDM1A/LSD1 activity in glioblastoma
R. Ferrarese, A. Izzo, G. Andrieux, S. Lagies, J. P. Bartmuss, A. P. Masilamani, A. Wasilenko, D. Osti, S. Faletti, R. Schulzki, S. Yuan, E. Kling, V. Ribecco, H. D. Heiland, S. G. Tholen, , M. S. Carro
This study identifies ZBTB18 as a regulator of SREBP gene expression in glioblastoma by modulating CTBP and LSD1 activity, leading to epigenetic repression of fatty acid synthesis.
bioRxiv · Apr 17, 2020 · PreprintCancer Biology