S. Yuan

SARS-CoV-2 infection activates inflammatory macrophages in vascular immune organoids

This study shows SARS-CoV-2 infection activates inflammatory macrophages in vascular immune organoids, upregulating interferon signaling linked to cytokine release syndrome.

Internalisation of integrin-bound extracellular matrix modulates invasive carcinoma cell migration

This study identifies 2β1 integrin and MAP3K1/p38 signaling as regulators of ECM internalization, which promotes cancer cell migration and invasion in breast and pancreatic cancers.

WTAP, transcriptionally regulated by p65, promotes inflammation through m6A modification and phase separation

This study identifies WTAP as a p65-regulated m6A writer that promotes inflammation via phase separation and m6A modification, offering a therapeutic target for hyperinflammation.

Immunities Specific to Both of the M Protein Ectodomain and RBD Synergize to Confer Cross-protection against SARS-CoV-2 Infections

This study identifies conserved M protein peptides that elicit cross-neutralizing antibodies against multiple SARS-CoV-2 variants, including Omicron, when combined with RBD-specific antibodies.

Stem cells tightly regulate dead cell clearance to maintain tissue fitness

The paper shows stem cells can temporarily act as phagocytes to clear dead cells, regulated by lipids and retinoids to maintain tissue health.

Antibodies that neutralize all current SARS-CoV-2 variants of concern by conformational locking

This study identifies two antibodies that neutralize all SARS-CoV-2 variants by locking the spike protein in a down conformation, showing a novel mechanism and potential for prophylaxis.

Phage administration with repeated intravenous doses leads to faster phage clearance in mammalian hosts

This study evaluates phage clearance and host responses to repeated intravenous phage doses in rats and monkeys, finding faster clearance and immune activation with repeated administration.

Physiological reprogramming in vivo mediated by Sox4 pioneer factor activity

This study shows Sox4 initiates hepatobiliary metaplasia by first closing hepatocyte enhancers and then opening biliary enhancers in adult liver cells.

Paradoxical activation of oncogenic signaling as a cancer treatment strategy

This study shows that inhibiting PP2A and WEE1 together can kill colon cancer cells by causing DNA replication collapse and cell death, and that resistance to this treatment suppresses tumor growth.

Human Early Syncytiotrophoblasts Are Highly Susceptible to SARS-CoV-2 Infection

This paper shows that human early syncytiotrophoblasts are highly susceptible to SARS-CoV-2 infection via ACE2 and demonstrates antiviral efficacy of remdesivir and GC376.

Development of highly potent non-covalent inhibitors of SARS-CoV-2 3CLpro

This study develops a potent non-covalent inhibitor of SARS-CoV-2 3CLpro, showing effective antiviral activity in human cells and animal models.

Spatially Resolved Metabolites in Stable and Vulnerable Human Atherosclerotic Plaques Identified by Mass Spectrometry Imaging

This study identifies spatially resolved metabolite differences between stable and unstable human atherosclerotic plaques using mass spectrometry imaging and RNA-seq integration.

Key mutations on spike protein altering ACE2 receptor utilization and potentially expanding host range of emerging SARS-CoV-2 variants

This study identifies key spike protein mutations in SARS-CoV-2 variants that enhance ACE2 receptor utilization across multiple animal species, potentially increasing host range and spillover risk.

A full spectrum PNGase activity analysis of R328 mutations on NGLY1

This study evaluates the impact of R328 mutations on NGLY1 activity using an in vitro assay, identifying dysfunctional, similar, and decreased activity mutations.

Phenethylamine-producing gut bacteria induces diarrhea-predominant irritable bowel syndrome by increasing serotonin biosynthesis

This study identifies Ruminococcus gnavus as a gut bacterium that contributes to IBS-D by increasing serotonin biosynthesis through phenethylamine production.

Immunomodulatory actions of a kynurenine-derived endogenous electrophile.

The paper identifies Kyn-CKA as a kynurenine-derived electrophile that reduces inflammation and prevents vaso-occlusion in sickle cell disease.

ASGR1 is a candidate receptor for SARS-CoV-2 that promotes infection of liver cells

The paper identifies ASGR1 as a potential receptor for SARS-CoV-2 that facilitates liver cell infection and suggests soluble ASGR1 as a therapeutic target.

The SARS-CoV-2 Omicron (B.1.1.529) variant exhibits altered pathogenicity, transmissibility, and fitness in the golden Syrian hamster model

The study compares the pathogenicity, transmissibility, and fitness of SARS-CoV-2 Omicron and Delta variants in golden Syrian hamsters, finding Omicron less pathogenic but more transmissible and capable of outcompeting Delta under immune pressure.

An elite broadly neutralizing antibody protects SARS-CoV-2 Omicron variant challenge

This study identifies a broadly neutralizing antibody, ZCB11, effective against SARS-CoV-2 Omicron and Delta variants, showing protection in hamsters.

Isolation and comparative analysis of antibodies that broadly neutralize sarbecoviruses

The paper identifies a human monoclonal antibody that neutralizes all tested sarbecoviruses and describes a new antibody class with potential for pandemic preparedness.

Cooperation between CYB5R3 and NOX4 via coenzyme Q mitigates endothelial inflammation

This study shows CYB5R3 modulates NOX4 activity via coenzyme Q to reduce endothelial inflammation, with in vivo and in vitro evidence of their interaction and functional dependency.

SARS-CoV-2 infection induces inflammatory bone loss in golden Syrian hamsters

This study shows SARS-CoV-2 infection causes bone loss in golden Syrian hamsters through cytokine dysregulation and osteoclastogenesis.

SARS-CoV-2 hijacks neutralizing dimeric IgA for enhanced nasal infection and injury

This study shows that dimeric IgA antibodies can enhance SARS-CoV-2 nasal infection and injury in Syrian hamsters by engaging CD209 as an alternative receptor.

WDR82-binding long non-coding RNA lncEry controls mouse erythroid differentiation and maturation

The paper identifies lncEry, a long non-coding RNA that regulates mouse erythroid differentiation and maturation by interacting with WDR82 to control Klf1 and globin gene transcription.

Mitochondrial dysfunction triggers secretion of the immunosuppressive factor α-fetoprotein

This study identifies a copper-linked signaling circuit triggered by mitochondrial dysfunction that leads to immune suppression via α-fetoprotein secretion.

A Robust High-throughput Fluorescent Polarization Assay for the Evaluation and Screening of SARS-CoV-2 Fusion Inhibitors

The paper develops a fluorescent polarization assay to screen SARS-CoV-2 fusion inhibitors, showing effective inhibitors with sub-mM concentrations and validating the assay with a high Z factor.

Transcription factor-like 5 is a potential DNA/RNA-binding protein essential for maintaining male fertility in mice.Running title: Tcfl5 is haploinsufficient in vivo

This study identifies Tcfl5 as a testis-specific protein essential for male fertility, showing that heterozygous mice are infertile and exhibit abnormalities in spermatids and spermatozoa.

Single Cell Raman-Deuterium Isotope Probing for Drug Resistance of Elizabethkingia spp.

This study uses single cell Raman-DIP to rapidly determine antimicrobial susceptibility of Elizabethkingia spp. and confirms minocycline and levofloxacin as first-line treatments.

Efficacy of ancestral receptor-binding domain, S1 and trimeric spike protein vaccines against SARS-CoV-2 variants B.1.1.7, B.1.351, and B.1.617.1

This study compares the efficacy of ancestral RBD, S1, and S-trimer vaccines against SARS-CoV-2 variants B.1.1.7, B.1.351, and B.1.617.1, finding that RBD and S-trimer induce higher neutralizing titers and maintain effectiveness against variants.

A Positive Regulatory Feedback Loop Between 1 EKLF/ KLF1 and TAL1/SCL2 Sustaining the Erythropoiesis

The paper identifies a positive feedback loop between EKLF/KLF1 and TAL1/SCL in sustaining erythropoiesis through direct transcriptional regulation.