Differentiation of mouse embryonic stem cells into cells with spermatogonia-like morphology with chemical intervention-dependent increased gene expression of LIM homeobox 1 (Lhx1).
C. Moshfegh, S. G. Rambow, S. A. Domenig, A. Pienkowska-Schelling, U. Bleul, V. Vogel
This study generates spermatogonia-like cells (CSMs) from mouse ES cells using a chemical intervention protocol, showing increased Lhx1 expression compared to controls.
bioRxiv · Oct 12, 2021Cell Biology