V. Vogel

Salmonella-driven Intestinal Edema in Mice is Characterized by Tensed Fibronectin Fibers

This study identifies tensed fibronectin fibers in Salmonella-induced intestinal edema in mice, highlighting their potential role in maintaining tissue integrity during inflammation.

Single-cell transcriptomics analysis reveals extracellular matrix remodelling in carious human dental pulp

This study uses single-cell RNA sequencing to show ECM remodelling and fibrosis-like changes in carious human dental pulp.

Blockage of Lamin-A/C loss diminishes the pro-inflammatory macrophage response

This study shows that reducing Lamin-A/C levels enhances pro-inflammatory macrophage responses, and inhibiting its degradation or the IFN-β-STAT pathway can suppress inflammation.

Differentiation of mouse embryonic stem cells into cells with spermatogonia-like morphology with chemical intervention-dependent increased gene expression of LIM homeobox 1 (Lhx1).

This study generates spermatogonia-like cells (CSMs) from mouse ES cells using a chemical intervention protocol, showing increased Lhx1 expression compared to controls.

Angicin, a novel bacteriocin of Streptococcus anginosus

This paper identifies Angicin, a novel bacteriocin from Streptococcus anginosus, which exhibits broad antimicrobial activity and stability under various conditions.

CdrS is a global transcriptional regulator influencing cell division in Haloferax volcanii

This study identifies CdrS as a transcriptional regulator essential for cell division in Haloferax volcanii, showing it influences metabolism, protein degradation, and cell division genes.

Nanoconfinement of Microvilli Alters Gene Expression and Boosts T cell Activation

This study shows that nanoporous surfaces enhance T cell activation by altering gene expression and promoting microvilli formation through size-dependent protein segregation.

Human induced pluripotent stem cell-derived vessels as dynamic atherosclerosis model on a chip

This study develops an in vitro atherosclerosis model using human induced pluripotent stem cell-derived vessels, showing comparable immune and mechanical features to human lesions.

Platelets exploit fibrillar adhesions to assemble fibronectin matrix revealing new force-regulated thrombus remodeling mechanisms

This study shows platelets form fibrillar adhesions and assemble fibronectin nanofibrils using IIbβ3 integrins, revealing new force-regulated thrombus remodeling mechanisms.

Maintenance of epithelial traits and resistance to mesenchymal reprogramming promote proliferation in metastatic breast cancer

This study shows that high EPCAM expression in metastatic breast cancer cells supports epithelial traits and plasticity, promoting metastatic outgrowth, while loss of epithelial traits inhibits it.

Global Modulation in DNA Epigenetics during Pro-Inflammatory Macrophage Activation

The paper investigates DNA methylation changes in macrophages during pro-inflammatory activation, showing rapid epigenetic modulation through oxidation and repair mechanisms.

Morphometric analysis of spread platelets identifies integrin αIIbβ3-specific contractile phenotype

The paper develops a morphometric screen to analyze platelet cytoskeletal organization and identifies integrin αIIbβ3-specific contractile phenotypes in response to matrix stiffness and inhibitors.