The initiation of the wound healing program is regulated by the convergence of mechanical and epigenetic cues
T. Bhatt, A. Hegde, R. Dey, A. Ketkar, A. Pulianmackal, A. Deb, S. Rampalli, C. Jamora
This study identifies how mechanical tension in the epidermis triggers DNA methylation changes via DNMT3a, leading to gene expression shifts that initiate wound healing.
bioRxiv · Oct 9, 2021 · PreprintCell Biology