Cryo-EM structure of the human Sirtuin 6-nucleosome complex
U. S. Chio, O. Rechiche, A. R. Bryll, J. Zhu, J. Feldman, C. Peterson, S. Tan, J.-P. Armache
The paper presents the cryo-EM structure of the human SIRT6-nucleosome complex, revealing how SIRT6 deacetylates histone H3 K9 and K56.
bioRxiv · Mar 17, 2023Biochemistry