The M2 Gene Is a Determinant of Reovirus-Induced Myocarditis
M. Dina Zita, M. B. Phillips, J. D. Stuart, A. R. Kumarapeli, A. J. Snyder, A. Paredes, V. Sridharan, M. Boerma, P. Danthi, K. W. Boehme
This study shows that the M2 gene from reovirus strain T3D, when substituted into T1L genetic background, causes lethal myocarditis in mice by enhancing viral replication and inflammation.
bioRxiv · Jul 16, 2021Microbiology