On-tissue spatially-resolved glycoproteomics guided by N-glycan imaging reveal global dysregulation of canine glioma glycoproteomic landscape
S. A. Malaker, J. Quanico, A. Raffo Romero, F. Kobeissy, S. Aboulouard, C. R. Bertozzi, I. Fournier, M. Salzet
This paper develops a spatially-resolved glycoproteomics approach combining MALDI imaging and LC-MS/MS to identify glycan patterns in canine gliomas, revealing dysregulated glycosylation in tumor and necrotic regions.
bioRxiv · Oct 2, 2020Cancer Biology