A transcriptomic continuum of differentiation arrest identifies myeloid interface acute leukemias with poor prognosis
J. Bond, A. Krzywon, L. Lhermitte, C. Roumier, A. Roggy, M. Belhocine, A. K. Kheirallah, P. Villarese, G. Hypolite, F. Garnache-Ottou, S. Castaigne, N. Boissel, V. Asnafi, C. Preudhomme, H. Dombret, , E. Macintyre
The paper identifies a transcriptomic continuum of differentiation arrest in acute leukemias, finding that myeloid/T-lymphoid interface leukemias (IALs) correlate with poor prognosis in AML.
bioRxiv · Dec 10, 2019Cancer Biology