E. Laurenti

Single-cell DNA sequencing reveals pervasive positive selection throughout preleukemic evolution

This study uses single-cell DNA sequencing to analyze preleukemic hematopoietic stem cells and finds pervasive positive selection throughout preleukemic evolution, with selective advantages ranging from 9%-24% per year.

Adaptation to ex vivo culture drives human haematopoietic stem cell loss of repopulation capacity in a cell cycle independent manner

This study shows that human LT-HSC loss of repopulation capacity during ex vivo culture occurs rapidly after adaptation, independent of cell cycle progression.

Human HLFneg placental erythro-myeloid progenitors give rise to HLA Class IIneg Hofbauer cells

The paper identifies placental erythro-myeloid progenitors (PEMPs) that generate Hofbauer cells, showing human primitive haematopoiesis occurs in the placenta, not just the yolk sac.

Single cell transcriptional characterization of human megakaryocyte lineage commitment and maturation

This study uses single-cell RNA sequencing to analyze human bone marrow HSCs and MKs, identifying MK primed HSC clusters and transcriptional changes during MK maturation and their association with myocardial infarction.

Quantitative and molecular differences distinguish adult human medullary and extramedullary haematopoietic stem and progenitor cell landscapes

This study compares HSPC landscapes in bone marrow, spleen, and peripheral blood using single-cell RNA-seq, revealing distinct molecular and functional differences in haematopoiesis across these sites.

A transcriptomic continuum of differentiation arrest identifies myeloid interface acute leukemias with poor prognosis

The paper identifies a transcriptomic continuum of differentiation arrest in acute leukemias, finding that myeloid/T-lymphoid interface leukemias (IALs) correlate with poor prognosis in AML.