DNA glycosylase NEIL2 prevents Fusobacterium-mediated inflammation and DNA damage in colonic epithelial cells
I. Sayed, A. Chakraborty, A. Ali, A. Sharma, A. Sahan, D. Sahoo, P. Ghosh, T. Hazra, S. Das
This study shows that NEIL2, a DNA repair enzyme, is downregulated by Fusobacterium infection, leading to DNA damage and inflammation in colonic epithelial cells, and this effect is specific to microsatellite stable colorectal cancers.
bioRxiv · Jun 11, 2020Immunology