A. Chakraborty

The L-lactate dehydrogenases of Pseudomonas aeruginosa are conditionally regulated but both contribute to survival during macrophage infection

This paper investigates the regulation and role of L-lactate dehydrogenases LldD and LldA in Pseudomonas aeruginosa, showing they are conditionally expressed and contribute to survival during macrophage infection.

Skeletal Muscle Mitochondrial Dysfunction Mediated by Pseudomonas aeruginosa Quorum Sensing Transcription Factor MvfR: Reversing Effects with Anti-MvfR and Mitochondrial-Targeted Compounds

This study investigates how Pseudomonas aeruginosa's MvfR quorum sensing transcription factor disrupts mitochondrial function in skeletal muscle and shows that inhibiting MvfR or using mitochondrial-targeted compounds can reverse these effects.

HOP/STIP1 is required for KSHV lytic replication.

This study shows HOP/STIP1 is essential for KSHV lytic replication in primary effusion cell lines.

Developing Bioactive Hydrogels Containing Cell-derived Extracellular Matrix: Implications in Drug and Cell-free Bone and Cartilage Repair

This study develops bioactive hydrogels containing cell-derived extracellular matrix for drug-free and cell-free bone and cartilage repair, showing induction of stem cell differentiation.

The Bacterial Quorum-Sensing Signal 2-Aminoacetophenone Rewires Immune Cell Bioenergetics through the PGC-1α/ERRα Axis to Mediate Tolerance to Infection

This study shows that the bacterial QS signal 2-AA modulates immune cell bioenergetics via the PGC-1α/ERRα axis, promoting immune tolerance and pathogen persistence.

Comparative metagenomic study unveils bacterial communities and their putative involvement in ecological success of two pine-feeding Ips beetle holobionts

This study compares bacterial communities in pine trees and two bark beetles before and after feeding, revealing life stage and environment effects on microbial associations.

KR158 spheres harboring slow-cycling cells recapitulate GBM features in an immunocompetent system

This study validates a murine model of glioblastoma stem cells that recapitulate human features and enables investigation of their interactions with the immune system.

Fructose-2,6-bisphosphate restores DNA repair activity of PNKP and ameliorates neurodegenerative symptoms in Huntingtons disease

This study shows that F2,6BP restores PNKP activity and alleviates neurodegenerative symptoms in HD and SCA3 by rescuing DNA repair and genome integrity.

Inhibition of the Eukaryotic Initiation Factor-2-α Kinase PERK Decreases Risk of Autoimmune Diabetes in Mice

This study shows that inhibiting PERK reduces autoimmune diabetes risk in mice by decreasing β cell immunogenicity and improving islet function.

Site-specific acetylation of polynucleotide kinase 3-phosphatase (PNKP) regulates its distinct role in DNA repair pathways

This study shows that acetylation of PNKP at K142 and K226 regulates its distinct roles in DNA repair pathways, with K142 involved in BER/SSBR and K226 in DSBR.

Metabolic transitions regulate global protein fatty acylation

This study shows that metabolic states like fed and fasted influence global protein fatty acylation, with glucose affecting palmitoylation and oleoylation through mitochondrial and retrograde signaling pathways.

Polymer biodegradation by Halanaerobium promotes reservoir souring during hydraulic fracturing.

The paper investigates how Halanaerobium metabolizes guar gum in produced water from hydraulic fracturing, showing that polymer biodegradation at 30°C generates fermentation intermediates that contribute to reservoir souring when introduced into subsurface environments at 60°C.

Identifying the proximate mechanisms that generate variation in nutritional plasticity for fecundity in Drosophila melanogaster

This study identifies that genetic variation in fecundity plasticity in Drosophila melanogaster is due to differences in food intake and conversion efficiency, not morphology.

SituSeq: An offline protocol for rapid and remote Nanopore amplicon sequence analysis

SituSeq enables rapid, offline analysis of 16S rRNA gene amplicons using Nanopore MinION and a laptop, validated across platforms with high sequence identity and community composition consistency.

A small-molecule myosin inhibitor as a targeted multi-stage antimalarial

This paper develops a small-molecule myosin inhibitor, KNX-115, effective against multiple stages of Plasmodium infection with high selectivity and potency.

FMRP directly interacts with R-loop and shows complex interplay with the DHX9 helicase

The paper was withdrawn due to duplicate submission and is not intended for citation.

ST6GAL1 sialyltransferase promotes acinar to ductal metaplasia and pancreatic cancer progression

This study identifies ST6GAL1 sialyltransferase as a promoter of acinar-to-ductal metaplasia and pancreatic cancer progression through glycosylation-dependent mechanisms.

A Mesenchymal Tumor Cell State Confers Increased Dependency on the BCL-XL Anti-apoptotic Protein in Kidney Cancer

The paper identifies a mesenchymal tumor cell state that increases dependency on BCL-XL in kidney cancer, showing anti-tumor efficacy of a BCL-XL inhibitor.

Dual Effects of NV-CoV-2 Biomimetic Polymer: An Antiviral regimen against COVID-19

This paper evaluates NV-CoV-2 polymer and its encapsulation of remdesivir (NV-CoV-2-R) for antiviral efficacy against COVID-19, showing improved stability and effectiveness compared to remdesivir alone.

Nanoviricides platform technology based NV-CoV-2 polymer increases the half-life of Remdesivir in vivo

This paper reports on a non-clinical study of NV-CoV-2 polymer and its encapsulation of Remdesivir, showing improved in vivo stability and safety in rats.

Wnt5A Signaling Blocks Progression of Experimental Visceral Leishmaniasis

This study shows that Wnt5A signaling reduces susceptibility to visceral leishmaniasis by limiting infection progression and preserving immune cell function in mice.

Geological processes mediate a subsurface microbial loop in the deep biosphere

The paper investigates a subsurface microbial loop mediated by geological processes, showing thermophilic endospores migrate from deep oil reservoirs to the seabed and re-enter the geosphere through sedimentation.

Nanoviricides Platform Technology based NV-387 polymer Protects Remdesivir from Plasma-Mediated Catabolism in vitro:Importance of its increased lifetime for in vivo action

The paper demonstrates that encapsulating remdesivir with the NV-387 polymer enhances its stability in plasma in vitro, potentially improving its in vivo efficacy.

Immunometabolic hijacking of immune cells by a Pseudomonas aeruginosa quorum-sensing signal

This study shows how Pseudomonas aeruginosa uses a quorum-sensing signal to reprogram macrophage metabolism, reducing energy and immune responses to promote pathogen persistence.

Regulation of DNA damage response by trimeric G-protein Signaling

This paper shows that GIV/Girdin modulates DNA damage response by suppressing HR and promoting NHEJ through BRCA1 sequestration and Akt pathway activation.

Identification of Pex34p as a component of the peroxisomal de novo biogenesis machinery in yeast

The paper identifies Pex34p as a crucial factor for de novo peroxisome biogenesis in yeast, alongside Pex25p, through genetic screening and interaction studies.

FMRP DIRECTLY INTERACTS WITH R-LOOP AND SHOWS COMPLEX INTERPLAY WITH THE DHX9 HELICASE

This study shows FMRP directly binds R-loops and inhibits DHX9 helicase activity, preventing R-loop accumulation and genome instability in FXS.

Hedgehog pathway inhibitors significantly reduce the formation of heterotopic ossification in a direct trauma/burn mouse model

This study shows that Hedgehog pathway inhibitors reduce heterotopic ossification in a trauma/burn mouse model by inhibiting osteoblast differentiation and systemic inflammation.

NAD+ Redox Imbalance in the Heart Exacerbates Diabetic Cardiomyopathy

This study shows that NAD+ redox imbalance worsens diabetic cardiomyopathy by impairing cardiomyocyte function and suggests NAMPT as a therapeutic target.

DNA glycosylase NEIL2 prevents Fusobacterium-mediated inflammation and DNA damage in colonic epithelial cells

This study shows that NEIL2, a DNA repair enzyme, is downregulated by Fusobacterium infection, leading to DNA damage and inflammation in colonic epithelial cells, and this effect is specific to microsatellite stable colorectal cancers.