Activation of silent secondary metabolite gene clusters by nucleosome map-guided positioning of the synthetic transcription factor VPR-dCas9
A. Schueller, L. Wolansky, H. Berger, L. Studt, A. Gacek-Matthews, M. Sulyok, J. Strauss
This paper introduces a synthetic transcription factor system to activate silent secondary metabolite gene clusters in Aspergillus nidulans by positioning VPR-dCas9 using nucleosome maps.
bioRxiv · Apr 2, 2020 · PreprintBioengineering