Topoisomerase 1 dependent R-loop deficiency drives accelerated replication and genomic instability
D. Sarni, A. Shtrikman, Y. S. Oren, B. Kerem
This study shows that increased TOP1 expression reduces R-loops, causing replication acceleration and DNA damage, and that restoring TOP1 or inhibiting replication can mitigate these effects.
bioRxiv · Jul 21, 2020Cell Biology