Higher anhedonia during withdrawal from initial opioid exposure is protective against subsequent opioid self-administration in rats.
Y. Swain, P. Muelken, A. Skansberg, D. Lanzdorf, Z. Haave, M. G. LeSage, J. C. Gewirtz, A. C. Harris
This study shows that higher anhedonia during opioid withdrawal in rats predicts lower vulnerability to subsequent opioid self-administration.
bioRxiv · Nov 12, 2019Animal Behavior & Cognition