Mechanical and chemical activation of GPR68 (OGR1) probed with a genetically-encoded fluorescent reporter
A. D. Ozkan, T. Gettas, A. Sogata, W. Phaychanpheng, J. J. Lacroix
The paper develops a fluorescent reporter, iGlow, to study GPR68 activation by mechanical and chemical stimuli, showing it responds to fluid shear stress, pH changes, and ogerin, and functions independently of Helix 8.
Journal of Cell Science · Aug 17, 2021Peer-reviewedBiophysics