Rugged fitness landscapes minimize promiscuity in the evolution of transcriptional repressors
A. T. Meger, M. A. Spence, M. Sandhu, C. J. Jackson, S. Raman
The paper characterizes the rugged fitness landscape of transcriptional repressors, showing rapid specificity switching and the role of regulatory crosstalk in shaping evolutionary paths.
bioRxiv · Oct 25, 2022Biochemistry