Author

M. A. Spence

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:protein sequence· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein folding & dynamics· 1 Research Focus:sequence-to-function modeling· 1

Frequent Co-Authors

C. J. Jackson· 3 shared A. Aggarwal· 1 shared A. M. Damry· 1 shared A. Norman· 1 shared A. T. Meger· 1 shared B. J. Bosch· 1 shared B. M. Lee· 1 shared C. Franck· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersBiochemistry

C. J. Jackson

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Author profile →

3 papers

Recent·Most cited

Ancestral reconstruction of polyethylene terephthalate degrading cutinases reveals a rugged and unexplored sequence-fitness landscape

V. Vongsouthi, R. Georgelin, D. Matthews, J. Saunders, B. M. Lee, J. Ton, A. M. Damry, R. Frkic, M. A. Spence, C. J. Jackson

This study uses ancestral sequence reconstruction to explore PET-degrading cutinase sequence space, revealing diverse evolutionary pathways and the effectiveness of LASE in mapping fitness landscapes.

bioRxiv · Apr 25, 2024Biochemistry

A broad-spectrum macrocyclic peptide inhibitor of the SARS-CoV-2 spike protein

V. Thijssen, D. L. Hurdiss, O. J. Debski-Antoniak, M. A. Spence, C. Franck, A. Norman, A. Aggarwal, N. J. Mokiem, D. A. A. van Dongen, S. W. Vermeir, M. Liu, W. Li, M. Chatziandreou, T. Donselaar, W. Du, , S. A. K. Jongkees

This paper discovers a macrocyclic peptide that inhibits SARS-CoV-2 and related sarbecoviruses by targeting a conserved site in the spike protein, offering a potential broad-spectrum antiviral.

bioRxiv · Nov 11, 2022 · PreprintBiochemistry

Rugged fitness landscapes minimize promiscuity in the evolution of transcriptional repressors

A. T. Meger, M. A. Spence, M. Sandhu, C. J. Jackson, S. Raman

The paper characterizes the rugged fitness landscape of transcriptional repressors, showing rapid specificity switching and the role of regulatory crosstalk in shaping evolutionary paths.

bioRxiv · Oct 25, 2022Biochemistry