Extrachromosomal Telomeres Derived from Excessive Strand Displacements
J. Lee, J. Lee, E. J. Sohn, A. Taglialatela, R. J. O'Sullivan, A. Ciccia, J. Min
This study identifies the generation mechanism of C-rich single-stranded DNAs and C-circles in ALT cancers using a novel assay, showing their origin from Okazaki fragment processing and CST-PP complex-mediated DNA synthesis.
bioRxiv · Jul 31, 2023Biochemistry