Author

A. Ciccia

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:chromatin & epigenetic regulation· 3 Assay:DNA methylation· 2 Approach:biophysical modeling· 1 Research Focus:cancer & tumor microenvironment· 1 Assay:CRISPR screen· 1 Approach:deep learning· 1

Frequent Co-Authors

A. A. Kelso· 1 shared A. Acharya· 1 shared A. Karamafrooz· 1 shared A. Taglialatela· 1 shared B. Izar· 1 shared C.-T. Cheng· 1 shared D. K. Ann· 1 shared E. J. Sohn· 1 shared

Activity by Year

2023-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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Curved chords = mutual co-authorship

1 shared paperCancer Biology

A. A. Kelso

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Massively parallel base editing screens to map variant effects on anti-tumor hallmarks of primary human T cells

Z. H. Walsh, P. Shah, N. Kothapalli, G. Nikolenyi, S. Shah, G. Leuzzi, M. Mu, P. Ho, S. Abuzaid, Z. D. Brodtman, N. Vasan, M. N. AlQuaraishi, J. D. Milner, A. Ciccia, J. C. Melms, B. Izar

This study uses base editing to screen for variants affecting T cell anti-tumor functions, identifying mutations that enhance tumor elimination with minimal off-target effects.

bioRxiv · Dec 13, 2023 · PreprintImmunology

Extrachromosomal Telomeres Derived from Excessive Strand Displacements

J. Lee, J. Lee, E. J. Sohn, A. Taglialatela, R. J. O'Sullivan, A. Ciccia, J. Min

This study identifies the generation mechanism of C-rich single-stranded DNAs and C-circles in ALT cancers using a novel assay, showing their origin from Okazaki fragment processing and CST-PP complex-mediated DNA synthesis.

bioRxiv · Jul 31, 2023Biochemistry

Mechanism of DNA unwinding by hexameric MCM8-9 in complex with HROB

A. Acharya, H. Bret, J.-W. Huang, M. Muetze, M. Goese, V. Kissling, R. Seidel, A. Ciccia, R. Guerois, P. Cejka

This study investigates how HROB regulates the DNA unwinding activity of the MCM8-9 helicase complex through structural and biochemical analyses.

bioRxiv · Jun 12, 2023 · PreprintBiochemistry

Arginine shortage induces replication stress and confers genotoxic resistance by inhibiting histone H4 translation and promoting PCNA polyubiquitination

Y.-C. Wang, A. A. Kelso, A. Karamafrooz, Y.-H. Chen, W.-K. Chen, C.-T. Cheng, Y. Qi, L. Gu, L. Malkas, H.-J. Kung, G.-L. Moldovan, A. Ciccia, J. M. Stark, D. K. Ann

bioRxiv · Jan 31, 2023 · PreprintCancer Biology