Cell based strain stiffening of a non-fibrous matrix as organizing principle for morphogenesis
D. Ruediger, K. Kick, A. Goychuk, A. Vollmar, E. Frey, S. Zahler
The paper identifies a mechanism where endothelial cells form networks by mechanically stiffening a non-fibrous matrix, independent of chemical cues, and shows how matrix topology and cell contractility influence this process.
bioRxiv · Oct 24, 2019Cell Biology