Impaired Function in Diabetic Patient iPSCs-derived Blood Vessel Organoids Stem from a Subpopulation of Vascular Cells
H. Naderi-Meshkin, M. Eleftheriadou, G. Carney, V. A. Cornelius, C.-A. Nelson, S. Kelaini, A. Yacoub, C. Donaghy, P. D. Dunne, R. Amirkhah, A. Zampetaki, L. Zeng, A. W. Stitt, D. J. Grieve, A. Margariti
This study identifies impaired vascular function in diabetic iPSCs-derived blood vessel organoids, highlighting a subpopulation of endothelial cells with increased ROS and oxidative phosphorylation.
bioRxiv · Jul 18, 2022 · PreprintCell Biology